2004 - Nonadherence among HIV patients

The article identifies cases of nonadherence among patients with HIV and can support the development of adherence enhancing interventions. A. E. Deschamps et.al.: Prevalence and correlates of nonadherence to antiretroviral therapy in a population of HIV patients using Medication Event Monitoring System. AIDS Patient Care STDS. 18 (11), 2004.

2004 – Electronic Monitors to Measure Adherence among Asthma Patients

This article is based on a study on the use of different methods, including electronic medication monitors, to evaluate adherence among adults hospitalized for asthma exacerbations. Jerry A. Krishnan et.al: Corticosteroid Use after Hospital Discharge among High-risk Adults with Asthma. American Journal of Respiratory and Critical Care Medicine, Vol. 170 pp. 1281-1285, 2004.

2006 - Good adherence result in positive health outcomes

Based on the data from 21 studies, this article argues that good adherence to drug therapy is associated with positive health outcomes. Moreover, the findings support the existence of a ‘healthy adherer’ effect. Scot H Simpson et.al.: A meta-analysis of the association between adherence to drug therapy and mortality. British Medical Journal (BMJ), Vol. 333, 15, 2006.

2005 – Need for effective interventions to enhance compliance

This article examines the effective interventions needed to enhance adherence to treatment for patients with type 2 diabetes. E. Vermeire et al: Interventions for improving adherence to treatment recommendations in people with type 2 diabetes mellitus (Review). Cochrane Database of Systematic Reviews 2005, Issue 2. Note: not direct link when you arrive on the website enter this text in the search button: Interventions for improving adherence to treatment recommendations in people with type 2 diabetes mellitus

2004 - Electronic Monitoring Useful in Improving Compliance for Diabetes Patients This review confirms that many diabetes patients have a poor compliance rate. However, electronic monitoring systems were proved useful in improving adherence and can be a help for healthcare providers in determining patients needing additional support. Joyce A. Cramer: A Systematic Review of Adherence With Medications for Diabetes. Diabetes Care, Vol. 27, no. 5, May 2004.

2003 – WHO Report on Adherence

This report published by WHO summarises the existing knowledge on adherence and the magnitude of the compliance problem. Moreover, it provides a review of nine specific diseases and adherence within each disease area. World Health Organization (WHO): Adherence to long term therapies. Evidence for action. 2003

2002 – Increased expenditures and inefficiency due to poor compliance

Poor compliance with prescribed drug regimens can result in decreased efficacy and increased medical expenditures. This article highlights the financial consequences of poor compliance using pharmacoeconomic evaluations. Dyfrig A. Hughes: Economic impact of poor compliance with pharmaceuticals. Expert Review of Pharmacoeconomics and Outcomes Research, Volume 2, Number 4, August 2002.

2001 – Financial Consequences of poor compliance

This articles argues that noncompliance is a serious health problem affecting individuals clinically as well as financially. Poorcompliance regimens are estimated to result in $100 billion annually in extra expenses. Frank Austria: Compliance and Persistency. Caremark’s Clinical Update, August 2001.

2003 – FDA's recommendations of dose-counters in metered-dose inhalers

This guidance reflects FDA's current recommendations regarding the integration of dose-counting mechanisms into metered-dose inhalers (MDIs) drug products for oral inhalation. U.S. Department of Health and Human Services. Food and Drug Administration (FDA): Integration of Dose-Counting Mechanisms into MDI Drug Products. March 2003.

2001 – Improve compliance by fewer daily doses of more effective drug

Bloom argues that if patients could take fewer daily doses of more effective drugs this could in turn improve compliance. Bernard S. Bloom: Daily regimen and compliance with treatment. British Medical Journal (BMJ), Vol. 323, 2001.

1999 – Electronic monitoring helps identify non-compliance

Failures to decrease blood pressure levels may be due to poor compliance in hypertensive patients. The paper evaluates using electronic monitoring of these patients with a pill container to measure their actual compliance rate. Joan Stephenson: Noncompliance May Cause Half of Antihypertensive Drug "Failures". The Journal of the American Medical Association (JAMA), Vol. 282, no. 4, 1999.

2005 – Electronic monitoring of liver transplant recipients

This article is based on a study where electronic event monitoring was used to to monitor liver transplant recipients. The use of electronic monitoring for this patient group resulted in an overall high level of compliance. Gerda Drent et.al: Prevalence of prednisolone (non)compliance in adult liver transplant recipients. Transplant International, Volume 18 Issue 8, August 2005.

2004 - Necessary to target non-compliance after transplantations

This article demonstrates that medication non-compliance doubles the risk for patients experiencing problems in the post-transplant period. Non-compliance is a continuous risk factor after heart transplantation that should be targeted by compliance-enhancing interventions. Fabienne Dobbels et.al: Effect of late medication non-compliance on outcome after heart transplantation: A 5-year follow-up. The Journal of Heart and Lung Transplantation, Vol. 23, Issue 11, November 2004.